Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses. 相似文献
研究非特异性腰痛(non-specific low back pain,NLBP)患者的腰骶结构特征及其影响因素。方法:招募筛选NLBP患者71例(NLBP组)及29例无腰痛的健康人群(Con组)。填写问卷评估疼痛程度和腰功能障碍,并分别拍摄矢状面及额状面的X光片,测定腰椎前凸程度和骨盆侧倾程度的相关指标。研究发现:①NLBP组腰椎前凸程度与Con组相比无显著性差异(P>0.05);②NLBP组与Con组相比骨盆发生明显侧倾(P<0.05);③性别对NLBP患者腰骶结构没有影响;④不同年龄的NLBP患者腰椎结构有发生不同的改变,青年患者与中老年患者相比,腰骶出现了显著的腰曲变直(P<0.05)及骨盆侧倾(P<0.01);⑤症状也会影响NLBP患者的腰椎前凸程度(P<0.05)。研究结论:①骨盆侧倾是NLBP患者的共性,可将该指标用于临床诊断和疗效评估;②不同年龄、性别和症状的NLBP患者进行康复时应有针对性。 相似文献
研究目的:对腰痛羽毛球运动员的部分功能进行测试,观察其活动范围、肌肉力量、肌电活动以及相应对称性。为了解羽毛球运动员损伤机制发生提供科学依据。研究对象:6名腰痛羽毛球运动员(男运动员4名,女运动员2名)。研究方法:对研究对象分别进行日本矫正外科协会(JOA)评分量表、躯干旋转、胸椎旋转、髋关节内外旋活动度、躯干等速旋转力量、等长背伸活动的肌电活动测试,并观察两侧差异比的平均值。研究结果:(1)腰痛运动员的躯干旋转、胸椎旋转以及髋关节外旋活动度平均差异比为(31.98±21.53)%,(19.8±17.08)%,(13.81±4.43)%大于10%,仅髋关节内旋活动度平均差异比为(5.62±5.63)%小于10%。胸椎和髋关节旋转动度有减小的趋势;(2)等速躯干旋转两侧峰力矩和平均功率差异没有显著性意义,峰力矩平均差异比为(5.45±1.78)%小于10%,而平均功率平均差异比为(12.78±11.40)%大于10%;(3)在等长背伸活动中,竖脊肌肌电活动的平均两侧差异比为(14.18±9.84)%大于10%,而多裂肌肌电活动的平均两侧差异比(9.90±7.92)%接近10%;竖脊肌和多裂肌的中位频率斜率(Median Frequency slope,MFs)均出现下降的趋势,但两侧差异比为(4.68±3.17)%,(5.35±5.40)%小于10%。结论:(1)腰痛羽毛球运动员躯干旋转、胸椎旋转、髋关节外旋活动范围存在对称性问题,且胸椎旋转、髋关节旋转有减少趋势;(2)躯干等速旋转平均功率存在对称性问题;(3)等长背伸任务中,竖脊肌和多裂肌出现疲劳,肌电活动存在对称性问题。 相似文献
The purpose of this study was to investigate the effects of interval aerobic training combined with strength exercise in the same training session on body composition, and glycaemic and lipid profile in obese rats. Sixteen lean Zucker rats and sixteen obese Zucker rats were randomly divided into exercise and sedentary subgroups (4 groups, n = 8). Exercise consisted of interval aerobic training combined with strength exercise in the same training session. The animals trained 60 min/day, 5 days/week for 8 weeks. Body composition, lipid and glycaemic profiles and inflammatory markers were assessed.
Results showed that fat mass was reduced in both lean and obese rats following the exercise training (effect size (95% confidence interval (CI)) = 1.8 (0.5–3.0)). Plasma low-density lipoprotein–cholesterol and fasting glucose were lower in the exercise compared to the sedentary groups (d = 2.0 (0.7–3.2) and 1.8 (0.5–3.0), respectively). Plasma insulin was reduced in exercise compared to sedentary groups (d = 2.1 (0.8–3.4)). Some exercise × phenotype interactions showed that the highest decreases in insulin, homeostatic model assessment-insulin resistance, fasting and postprandial glucose were observed in the obese + exercise group (all, P < 0.01). The findings of this study suggest that interval aerobic training combined with strength exercise would improve body composition, and lipid and glycaemic profiles, especially in obese rats. 相似文献